Targeting Tissue Factor to Tumor Vasculature to Induce Tumor Infarction
نویسندگان
چکیده
منابع مشابه
Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature.
Selective occlusion of tumor vasculature was tested as a therapy for solid tumors in a mouse model. The formation of blood clots (thrombosis) within the tumor vessels was initiated by targeting the cell surface domain of human tissue factor, by means of a bispecific antibody, to an experimentally induced marker on tumor vascular endothelial cells. This truncated form of tissue factor (tTF) had ...
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ژورنال
عنوان ژورنال: Cancers
سال: 2021
ISSN: 2072-6694
DOI: 10.3390/cancers13112841